Mark Depristo
Something New at BigHat Biosciences
Los Altos, California, United States
Summary
👤
Senior🎓
Top SchoolMark DePristo is a seasoned technology and biotech leader with a track record spanning big tech, academia, and startups. He founded and led BigHat Biosciences (2019-2025), a Bay Area company applying machine learning and synthetic biology to design safer, more effective antibody therapies. Earlier, he built and led Google Brain's Genomics team, where he helped create DeepVariant and Nucleus, two influential open-source tools that catalyzed machine learning in genomics. As co-director of Medical and Population Genetics at the Broad Institute, he conceived the Genome Analysis Toolkit (GATK), a cornerstone in next-generation sequencing data analysis used worldwide. He brings a strong scientific foundation (PhD in Biochemistry from Cambridge as a Marshall Scholar; BA in Mathematics and Computer Science from Northwestern; Damon Runyon Fellow) and a prolific publication record with over 130,000 citations. Based in Los Altos, California, he continues to advise and shape early-stage biotech through Ephla Bio, Mirvie, EverlyWell, Inductive Bio, and his current venture, Something New.
10 years of coding experience
14 years of employment as a software developer
Ph.D., Biochemistry, Ph.D., Biochemistry at University of CambridgeBA, Mathematics and Computer Science, 3.9/4.0, BA, Mathematics and Computer Science, 3.9/4.0 at Northwestern University
English
Github Skills (75)
throughput10
genomics10
bam10
genetic10
htslib10
fasta10
protobuf10
genome10
serialization10
sequencing10
containment10
sam10
bioinformatics10
interval-tree10
protocol-buffers9
Programming languages (4)
Github contributions (5)
depristo/prototest
Jul 2018 - Jul 2018
Contributions:11 pushes, 2 branches in 1 day
depristo/protobuf
Jun 2018 - Jul 2018
Protocol Buffers - Google's data interchange format
Contributions:5 pushes in 20 days
protocol-buffersgoogle-protocol-buffersinterchange-formatprotobufbuffers
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